​​Product Details

Publications & Research

References for Technology
and Protocol Development
  • Gorodetskyi I G, Gorodnichenko A I, Tursin P S, Reshetnyak V K, Uskov, O N: Non-invasive interactive Neurostimulation in the post-operative recovery of patients with a trochanteric fracture of the femur. J Bone Joint Surg [Br]2007;89-B:1488-94.

  • Maale G: The effect of the InterX 5000 on pain reduction in the severe chronic orthopedic patient. Presented at International Congress of Technology in Arthroplasty, Kyoto, Japan, September 29-October 2, 2005

  • I. G. Gorodetskyi et al, The effects of non-invasive, interactive Neurostimulation on pain and edema during post-surgical rehabilitation following internal fixation of unstable bi-malleolar ankle fractures, Presented as a poster by Dr James Dillard at the IASP 2008, Glasgow, Scotland. Accepted for publication Dec 2009, Journal of Foot and Ankle Surgery

  • Jan Magnus Bjordal, Mark I. Johnson, Anne Elisabeth Ljunggreen; Transcutaneous electrical nerve stimulation (TENS) can reduce postoperative analgesic consumption. A meta-analysis with assessment of optimal treatment parameters for postoperative pain

  • European Journal of Pain 7 (2003) 181-188

  • Melzack R: Prolonged relief of pain by brief, intense transcutaneous somatic stimulation. Pain. 1975;1: 357-373.

  • Somers D, Clemente F R, TENS for the management of neuropathic pain: The effects of frequency and electrode position on prevention of allodynia in a rat model of CRPS type II, Phys Ther, Vol. 86, no.5, 2006: pg 698-709

  • Breit R, Van der Wall H, Transcutaneous Electrical Nerve Stimulation for Postoperative Pain Relief After Total Knee Arthroplasty, The Journal of Arthroplasty Vol. 19 No. 1 2004

  • Carroll D, Tramer M, McQuay H, Nye B, Moore A. Randomization is important in studies with pain outcomes: Systematic review of transcutaneous electrical nerve stimulation in acute postoperative pain. British Journal of Anaesthesia 1996; 77:798-803

  • Walsh D. Transcutaneous electrical nerve stimulation. In Acupuncture and Related Techniques in Physical Therapy. Eds. Hopwood V, Lovesey M, Mokone S. New York: Churchill Livingston; 1997: 111 – 118.

  • Schultz SP, Driban JB, and Swanik CB. The evaluation of electrodermal properties in the identification of myofascial trigger points. Arch Phys Med Rehabil. 2007;88(6): 780-784.

  • Agatha P. Colbert, Jinkook Yun, Adrian Larsen, Tracy Edinger, William L. Gregory and Tran Thong,, Skin Impedance Measurements for Acupuncture Research: Development of a Continuous Recording System. eCAM 2008 5(4):443-450; doi:10.1093/ecam/nem060

  • Korr, I.M., H.M. Wright and J.A. Chace. Cutaneous patterns of sympathetic activity in clinical abnormalities of the musculoskeletal system. Acta Neuroveg, 25:589-606, 1964

  • Zang Hee Cho Ph.D. Neuro-Acupuncture, Volume 1: Neuroscience Basics ISBN: 9780970645517; Calif: Q-Puncture Inc; 2001

  • Lee KH, Chung JM, Willis WD. Inhibition of primate spinothalamic tract cells by TENS. J Neurosurg. 1985; 62: 276-287

  • Linda S. Chesterton, Nadine E. Foster, Christine C. Wright, G. David Baxter and Panos Barlas

  • Effects of TENS frequency, intensity and stimulation site parameter manipulation on pressure pain thresholds in healthy human subjects

  • Pain, Volume 106, Issues 1-2, November 2003, Pages 73-80

  • Garrison DW, Foreman RD: Effects of prolonged transcutaneous electrical nerve stimulation (TENS) and variation of stimulation variables on dorsal horn cell activity, Eur J Phys Med Rehabil 6:87-94, 1997

  • Reilly JP, Applied Bioelectricity: From Electrical Stimulation to Electropathology, 1998 Springer-Verlag NY. pg 130 and 233

  • Christie Q. Huang, Robert K. Shepherd Reduction in excitability of the auditory nerve following electrical stimulation at high stimulus rates: Varying Effects of electrode surface area Hearing Research 146 (2000) 57-71

  • G Pyne-Geithman G, Clark J F, InterX elicits significantly greater physiological response than TENS: Lymphocyte metabolism and Cytokine production. Presented as a poster at IASP 2010, Montreal, Canada. Aug. 29th 2010.

  • Han J S, Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends in Neurosciences, Vol. 26, No.1, January 2003

  • Hamza, M.A. et al. (1999) Effect of the frequency of transcutaneous electrical nerve stimulation on the postoperative opioid analgesic requirement and recovery profile. Anesthesiology 91, 1232-1238

  • Chandran P, Sluka KA. Development of opioid tolerance with repeated transcutaneous electrical nerve stimulation administration. Pain. 2003;102:195-201

  • Josimari M. DeSantana, PhD, Valter J. Santana-Filho, MSc, Kathleen A. Sluka, PhD: Modulation Between High- and Low-Frequency Transcutaneous Electric Nerve Stimulation Delays the Development of Analgesic Tolerance in Arthritic Rats Arch Phys Med Rehabil Vol 89, April 2008: pg 754-760

FDA Innovation Challenge References
  1. https://www.interxtechnologies.com/research

  2. https://www.interxtechnologies.com/opioid-patient-data

  3. https://www.interxtechnologies.com/case-studies

  4. https://www.interxtechnologies.com/pro-testimonials

  5. Muhuri PK, Gfroerer JC, Davies MC. Associations of Nonmedical Pain Reliever Use and Initiation of Heroin Use in the United States. CBHSQ Data Rev. August 2013.

  6. Vivolo-Kantor, AM, Seth, P, Gladden, RM, et al. Vital Signs: Trends in Emergency Department Visits for Suspected Opioid Overdoses--United States, July 2016-September 2017. Centers for Disease Control and Prevention

  7. Vowles KE, McEntee ML, Julnes PS, Frohe T, Ney JP, van der Goes DN. Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis. Pain. 2015;156(4):569-576. doi:10.1097/01.j.pain.0000460357.01998.f1.

  8. https://www.ncbi.nlm.nih.gov/pubmed/18443635

  9. https://www.interxtechnologies.com/testimonials

  10. https://www.interxtechnologies.com/opioid-patient-data

  11. https://online.boneandjoint.org.uk/doi/full/10.1302/0301-620X.89B11.19352

  12. https://www.ncbi.nlm.nih.gov/pubmed/18443635

  13. https://www.samhsa.gov/data/sites/default/files/NSDUH-DetTabs-2016/NSDUH-DetTabs-2016.pdf

  14. https://www.painweek.org/news_posts/cost-of-chronic-pain-care-at-32000-per-patient-annually.html

  15. https://www.spine-health.com/treatment/pain-management/disadvantages-and-risks-spinal-cord-stimulation

  16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182948/

  17. https://www.interxtechnologies.com/casestudylinsey

  18. https://www.interxtechnologies.com/opioid-patient-data

  19. https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm607884.htm

  20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182948/

  21. https://docs.wixstatic.com/ugd/87b22d_04167337264440db8b66cc341e5a3e52.pdf

  22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943001/

  23. https://www.hindawi.com/journals/bmri/2017/5856071/abs/